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Study Suggests Caffeine and Exercise May Be Protective Against Skin Cancer Caused By Sun Exposure... 

Coffee pouringThe combined effects of exercise plus caffeine consumption may be able to ward off skin cancer and also prevent inflammation related conditions including obesity-linked cancers.
"We found that this combination treatment can decrease sunlight-caused skin cancer formation in a mouse model," said Yao-Ping Lu, Ph.D., associate research professor of chemical biology and director of skin cancer prevention at the Rutgers Ernest Mario School of Pharmacy in Piscataway, N.J. He presented these findings at the American Association for Cancer Research  Annual Meeting held in Chicago.

"I believe we may extrapolate these findings to humans and anticipate that we would benefit from these basic combination treatments as well," Dr. Lu added.
The researchers evaluated the effects of caffeine and exercise on laboratory mice at high risk for developing skin cancer. Results showed that mice that took a dose of caffeine and exercised with a running wheel experienced 62 percent fewer skin tumors. The volume of tumors also decreased by 85 percent compared with the mice that did not consume caffeine or exercise.

Positive effects were also found with either caffeine or exercise alone, but to a lesser degree. Interestingly, he researchers observed a 27 percent reduction in tumors in the caffeine-only mice and a 61 percent reduction in tumor size. In the exercise-only mice, researchers discovered that tumor activity decreased by 35% and tumor volume decreased by 70%. 

fitness woman at GymThe researchers also found that exercise and caffeine reduced weight and inflammation. They fed mice a high-fat diet of omega-6 fatty acid-rich foods and measured the volume of the parametrial fat pad (the largest fat area in a mouse) after two weeks of exercise and/or caffeine treatment.
Mice that had caffeine and exercised had a fat  weight decrease of 63%. Caffeine-only mice had a 30% decrease, and exercise-only mice had a 56% decrease. The development and size of cancer decreased as well. Researchers believe the correlation is inflammation, which dropped as much as 92% in mice that exercised and consumed caffeine.


American Association for Cancer Research 
(AACR - 2012, April 3).
Caffeine and exercise may be protective against skin cancer caused by sun exposure, study suggests.


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