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Boosting Immunity with Vitamin D3
and Omega-3 To Fight Alzheimer's

Nutritional Compounds Including Vitamin D3 and Omega-3 Fish Oils
Could Be Highly-Beneficial In Boosting Immunity To Help Fight Alzheimer's...

Nutritional Approaches Now Being Studied
For Helping Clear Brain Plaques Present in Alzheimer's Disease


Plaques Alzheimers
Alzheimer's brain tissue exhibits many fewer nerve cells and synapses than a healthy brain, due to the presence of plaques (abnormal clusters of protein fragments) build up between nerve cells; tangled- twisted strands of proteins that contain dead and dying nerve cells.

In a study from the University of California Los Angeles (UCLA; California, USA), researchers drew blood samples from both Alzheimer's patients and healthy patients. They isolated macrophages , which are the blood components that are responsible for disposing of amyloid-beta and other waste products in the brain and body.

The team incubated the immune cells overnight with amyloid-beta. They added either an active form of vitamin D3 (1alpha,25-dihydroxyvitamin D3)  or an active form of the omega-3 fatty acid DHA (resolvin D1) to some of the cells to gauge the effect they had on inflammation and amyloid-beta absorption. 

The team observed that 1alpha, 25-dihydroxyvitamin D3 as well as the resolvin D1 improved the ability of the Alzheimer's disease patients' macrophages to devour amyloid-beta, and they also inhibited the cell death that is induced by amyloid-beta.

Researchers observed that each nutrition molecule utilized different receptors and common signaling
pathways to accomplish this beneficial task. The researchers are reporting about the positive potential for nutritional approaches to fight  Alzheimer's, stating "Our new study sheds further light on a possible role for
nutritional substances such as vitamin D3 and omega-3 in boosting immunity to help fight Alzheimer's."

University of California Los Angeles 
(UCLA ; California, USA)
Mizwicki MT, Menegaz D, Zhang J, Barrientos-Durán A, Tse S, Cashman JR, Griffin PR, Fiala M.  "Genomic and nongenomic signaling induced by 1α,25(OH)2-vitamin D3 promotes the recovery of amyloid-[beta] phagocytosis by Alzheimer's disease macrophages."  J Alzheimers Dis. 2012;29(1):51-62.
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