with Vitamin D3
and Omega-3 To Fight Alzheimer's Nutritional Compounds Including
Vitamin D3 and Omega-3 Fish Oils
Could Be Highly-Beneficial In Boosting Immunity To Help Fight
Nutritional Approaches Now Being
For Helping Clear Brain Plaques Present in Alzheimer's Disease
Alzheimer's brain tissue exhibits many fewer nerve cells and synapses
than a healthy brain, due to the presence of plaques (abnormal clusters
of protein fragments) build up between nerve cells; tangled- twisted
strands of proteins that contain dead and dying nerve cells.
In a study from the University of
California Los Angeles (UCLA; California, USA), researchers drew blood
samples from both Alzheimer's patients and healthy patients. They
isolated macrophages , which are the blood components that are
responsible for disposing of amyloid-beta and other waste products in
the brain and body.
The team incubated the immune cells overnight with amyloid-beta. They
added either an active form of vitamin D3 (1alpha,25-dihydroxyvitamin
D3) or an active form of the omega-3 fatty acid DHA (resolvin D1) to
some of the cells to gauge the effect they had on inflammation and
The team observed that 1alpha, 25-dihydroxyvitamin D3 as well as the
resolvin D1 improved the ability of the Alzheimer's disease patients'
macrophages to devour amyloid-beta, and they also inhibited the cell
death that is induced by amyloid-beta.
Researchers observed that each nutrition
molecule utilized different receptors and common signaling pathways to accomplish this beneficial task. The researchers are
reporting about the positive potential for nutritional approaches to
fight Alzheimer's, stating "Our new study sheds further light on a
possible role for nutritional substances such as vitamin D3 and omega-3 in boosting
immunity to help fight Alzheimer's."
University of California Los Angeles
(UCLA ; California, USA)
Mizwicki MT, Menegaz D, Zhang J,
Barrientos-Durán A, Tse S, Cashman JR, Griffin PR, Fiala M.
"Genomic and nongenomic signaling induced by 1α,25(OH)2-vitamin D3
promotes the recovery of amyloid-[beta] phagocytosis by Alzheimer's
disease macrophages." J Alzheimers Dis. 2012;29(1):51-62.